Genetic Modifiers Play a Substantial Role in Diabetes Complicating Cystic Fibrosis | Zendy

Scott M. Blackman | Zendy; Stephanie Hsu | Zendy; Lori L. Vanscoy | Zendy; Joseph M. Collaco | Zendy; Sarah E. Ritter | Zendy; Kathleen Naughton | Zendy; Garry R. Cutting | Zendy

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Genetic Modifiers Play a Substantial Role in Diabetes Complicating Cystic Fibrosis

Author(s) -

Scott M. Blackman,

Stephanie Hsu,

Lori L. Vanscoy,

Joseph M. Collaco,

Sarah E. Ritter,

Kathleen Naughton,

Garry R. Cutting

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2186

Subject(s) - diabetes mellitus , cystic fibrosis , medicine , sibling , endocrinology , cystic fibrosis related diabetes , population , cystic fibrosis transmembrane conductance regulator , concordance , physiology , insulin resistance , impaired glucose tolerance , psychology , developmental psychology , environmental health

Insulin-requiring diabetes affects 7-15% of teens and young adults, and more than 25% of older adults with cystic fibrosis (CF). Pancreatic exocrine disease caused by CF transmembrane conductance regulator (CFTR) dysfunction underlies the high rate of diabetes in CF patients; however, only a subset develops this complication, indicating that other factors are necessary.

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