Open AccessInhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists
Author(s) -
Mabrouka Doghman,
Julie Cazareth,
Dominique Douguet,
Franck Madoux,
Peter Hodder,
Enzo Lalli
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2163
Subject(s) - adrenocortical carcinoma , steroidogenic factor 1 , cell growth , endocrinology , medicine , steroid hormone , hormone , chemistry , transcription factor , biology , gene , biochemistry , nuclear receptor
Transcription factor steroidogenic factor-1 (SF-1) plays a pivotal role in the control of adrenocortical cell steroidogenesis and proliferation. SF-1 amplification and overexpression are found in most cases of childhood adrenocortical tumors (ACTs).