Human Glucocorticoid Receptor α Gene (NR3C1) Pharmacogenomics: Gene Resequencing and Functional Genomics | Zendy

Nifang Niu | Zendy; Venkatraman Manickam | Zendy; Krishna R. Kalari | Zendy; Irene Moon | Zendy; Linda L. Pelleymounter | Zendy; Bruce W. Eckloff | Zendy; Eric D. Wieben | Zendy; Daniel J. Schaid | Zendy; Liewei Wang | Zendy

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Human Glucocorticoid Receptor α Gene (NR3C1) Pharmacogenomics: Gene Resequencing and Functional Genomics

Author(s) -

Nifang Niu,

Venkatraman Manickam,

Krishna R. Kalari,

Irene Moon,

Linda L. Pelleymounter,

Bruce W. Eckloff,

Eric D. Wieben,

Daniel J. Schaid,

Liewei Wang

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-2109

Subject(s) - glucocorticoid receptor , pharmacogenomics , context (archaeology) , nuclear receptor , biology , nuclear receptor coactivator 2 , gene , glucocorticoid , functional genomics , genomics , genetics , computational biology , endocrinology , transcription factor , genome , paleontology

The human glucocorticoid receptor alpha (GRalpha) is a nuclear hormone receptor that regulates multiple physiological and pathophysiological processes. There are large variations in both physiological and therapeutic response to glucocorticoids. Multiple previous studies suggested that genetic polymorphisms in GRalpha (NR3C1) might play an important role.

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