Open AccessCoexpression of Dopamine and Somatostatin Receptor Subtypes in Corticotroph Adenomas
Author(s) -
Christiaan de Bruin,
Alberto M. Pereira,
Richard A. Feelders,
Johannes A. Romijn,
Ferdinand Roelfsema,
Diane M. Sprij-Mooij,
Maarten O. van Aken,
AartJan van der Lelij,
Wouter W. de Herder,
Steven W. J. Lamberts,
Leo J. Hofland
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-2101
Subject(s) - corticotropic cell , somatostatin , somatostatin receptor , endocrinology , medicine , adenoma , receptor , somatostatin receptor 2 , cushing's disease , biology , pituitary adenoma , pituitary gland , disease , hormone
Previous studies have demonstrated the expression of somatostatin receptor subtypes (mainly sst(5)) and dopamine (DA) receptor subtypes (mainly D(2)) in smaller series of human corticotroph adenomas. In line with these findings, sst(5) and D(2)-targeting agents have already been used clinically in patients with Cushing's disease (CD) and have shown promising results in subsets of patients. To what extent these receptor subtypes are coexpressed within individual adenomas, is not known however.
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