Open AccessAssociation of the Calcium-Sensing Receptor Gene with Blood Pressure and Urinary Calcium in African-Americans
Author(s) -
Jeesun Jung,
Tatiana Foroud,
George J. Eckert,
Leah FluryWetherill,
Howard J. Edenberg,
Xiaoling Xuei,
Syed-Adeel Zaidi,
J. Howard Pratt
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-1861
Subject(s) - linkage disequilibrium , single nucleotide polymorphism , endocrinology , medicine , blood pressure , population , context (archaeology) , biology , genetics , genotype , gene , paleontology , environmental health
Calcium binding to the Ca-sensing receptor (CASR) expressed in thick ascending limb inhibits the Na,K,2Cl cotransporter, which decreases sodium reabsorption and secondarily decreases Ca reabsorption. CASR gene variants could influence blood pressure (BP) by affecting Na retention.
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