Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells | Zendy

Marina Montagnani Marelli | Zendy; Roberta M. Moretti | Zendy; Stefania Mai | Zendy; Joanna Januszkiewicz-Caulier | Zendy; Marcella Motta | Zendy; Patrízia Limonta | Zendy

Open Access

Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells

Author(s) -

Marina Montagnani Marelli,

Roberta M. Moretti,

Stefania Mai,

Joanna Januszkiewicz-Caulier,

Marcella Motta,

Patrízia Limonta

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1741

Subject(s) - prostate cancer , gene silencing , gonadotropin releasing hormone , endocrinology , medicine , forskolin , transfection , cancer cell , cell growth , receptor , small interfering rna , biology , cancer research , chemistry , cancer , cell culture , hormone , luteinizing hormone , gene , biochemistry , genetics

GnRH-II has been shown to exert a strong antiproliferative action on tumors of the female reproductive system. The data so far reported on the effects of GnRH-II on prostate cancer growth are controversial. Moreover, it is still unclear through which receptor [type I or type II GnRH-receptor (GnRH-R)] GnRH-II might modulate cancer cell proliferation.

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