Effects of Somatostatin Analogs on a Growth Hormone-Releasing Hormone Secreting Bronchial Carcinoid,in Vivoandin VitroStudies | Zendy

Mandy van Hoek | Zendy; Leo J. Hofland | Zendy; Yolanda B. de Rijke | Zendy; Francien H. van Nederveen | Zendy; R.R. de Krijger | Zendy; P. M. van Koetsveld | Zendy; Steven W. J. Lamberts | Zendy; A. J. van der Lely | Zendy; Wouter W. de Herder | Zendy; Richard A. Feelders | Zendy

Open Access

Effects of Somatostatin Analogs on a Growth Hormone-Releasing Hormone Secreting Bronchial Carcinoid,in Vivoandin VitroStudies

Author(s) -

Mandy van Hoek,

Leo J. Hofland,

Yolanda B. de Rijke,

Francien H. van Nederveen,

R.R. de Krijger,

P. M. van Koetsveld,

Steven W. J. Lamberts,

A. J. van der Lely,

Wouter W. de Herder,

Richard A. Feelders

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1712

Subject(s) - somatostatin , somatostatin receptor , acromegaly , endocrinology , medicine , octreotide , in vivo , somatostatin receptor 2 , growth hormone–releasing hormone , in vitro , hormone , biology , growth hormone , biochemistry , microbiology and biotechnology

A 56-yr-old woman presented with acromegaly, a pulmonary mass, and elevated levels of GHRH, GH, and IGF-I. Histological examination revealed a bronchial carcinoid with positive staining for GHRH. Somatostatin analogs (SAs) can play an important role in the treatment of neuroendocrine tumors, dependent on the somatostatin receptor subtype (sst) expression pattern. The sst pattern in bronchial carcinoids and effects of SAs have not been extensively investigated, particularly not for the recently developed universal SA SOM230 (Pasireotide) that has high affinity for sst1, 2, 3, and 5.

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