Is Obesity Our Genetic Legacy? | Zendy

Alexandra I. F. Blakemore | Zendy; Philippe Froguel | Zendy

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Is Obesity Our Genetic Legacy?

Author(s) -

Alexandra I. F. Blakemore,

Philippe Froguel

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1676

Subject(s) - obesity , disease , genetic association , biology , missing heritability problem , genome wide association study , candidate gene , heritability , bioinformatics , genetics , evolutionary biology , medicine , gene , single nucleotide polymorphism , genotype , endocrinology , pathology

To design rational management regimes and identify novel therapeutic targets, it is essential to understand the biological drivers of the current epidemic of obesity. This review describes our current knowledge of genetic factors in obesity, drawing functional parallels in the underlying neuroendocrine mechanisms and suggesting promising new directions for research.

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