Evidence for Association between Polycystic Ovary Syndrome (PCOS) andTCF7L2and Glucose Intolerance in Women with PCOS andTCF7L2 | Zendy

Assel Biyasheva | Zendy; Richard S. Legro | Zendy; Andrea Dunaif | Zendy; Margrit Urbanek | Zendy

Open Access

Evidence for Association between Polycystic Ovary Syndrome (PCOS) andTCF7L2and Glucose Intolerance in Women with PCOS andTCF7L2

Author(s) -

Assel Biyasheva,

Richard S. Legro,

Andrea Dunaif,

Margrit Urbanek

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1664

Subject(s) - tcf7l2 , polycystic ovary , insulin resistance , type 2 diabetes , type 2 diabetes mellitus , endocrinology , medicine , endocrine system , context (archaeology) , candidate gene , biology , diabetes mellitus , hormone , gene , genetics , genotype , single nucleotide polymorphism , paleontology

Of the recently identified type 2 diabetes mellitus (T2D) susceptibility loci, transcription factor 7-like 2 (TCF7L2) confers the greatest relative risk for T2D and significantly predicts conversion to T2D in persons with impaired glucose tolerance. TCF7L2 is, therefore, also a strong candidate gene for polycystic ovary syndrome (PCOS), a common endocrine disorder characterized by androgen excess and menstrual irregularities and associated with insulin resistance and a 7-fold increased risk for T2D.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research