The Association ofENPP1K121Q with Diabetes Incidence Is Abolished by Lifestyle Modification in the Diabetes Prevention Program | Zendy

Allan F. Moore | Zendy; Kathleen A. Jablonski | Zendy; Clinton C. Mason | Zendy; Jarred B. McAteer | Zendy; Richard Arakaki | Zendy; Barry J. Goldstein | Zendy; Steven E. Kahn | Zendy; Abbas E. Kitabchi | Zendy; Robert L. Hanson | Zendy; William C. Knowler | Zendy; José C. Florez | Zendy

Open Access

The Association ofENPP1K121Q with Diabetes Incidence Is Abolished by Lifestyle Modification in the Diabetes Prevention Program

Author(s) -

Allan F. Moore,

Kathleen A. Jablonski,

Clinton C. Mason,

Jarred B. McAteer,

Richard Arakaki,

Barry J. Goldstein,

Steven E. Kahn,

Abbas E. Kitabchi,

Robert L. Hanson,

William C. Knowler,

José C. Florez

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1583

Subject(s) - type 2 diabetes , diabetes mellitus , allele , insulin resistance , context (archaeology) , medicine , single nucleotide polymorphism , endocrinology , gene , genetics , biology , genotype , paleontology

Insulin resistance is an important feature of type 2 diabetes. Ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling, and a recent meta-analysis reported a nominal association between the Q allele in the K121Q (rs1044498) single nucleotide polymorphism in its gene ENPP1 and type 2 diabetes. OBJECTIVE AND INTERVENTION: We examined the impact of this polymorphism on diabetes incidence as well as insulin secretion and sensitivity at baseline and after treatment with a lifestyle intervention or metformin vs. placebo in the Diabetes Prevention Program (DPP). DESIGN, SETTING, PARTICIPANTS, AND OUTCOME: We genotyped ENPP1 K121Q in 3548 DPP participants and performed Cox regression analyses using genotype, intervention, and interactions as predictors of diabetes incidence.

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