Effect of Tumor Necrosis Factor-α on Estrogen Metabolism and Endometrial Cells: Potential Physiological and Pathological Relevance | Zendy

Salama A. Salama | Zendy; Marwa Kamel | Zendy; Concepcion DiazArrastia | Zendy; Xia Xu | Zendy; Timothy D. Veenstra | Zendy; Sana M. Salih | Zendy; Shaleen K. Botting | Zendy; Rajiv Kumar | Zendy

Open Access

Effect of Tumor Necrosis Factor-α on Estrogen Metabolism and Endometrial Cells: Potential Physiological and Pathological Relevance

Author(s) -

Salama A. Salama,

Marwa Kamel,

Concepcion DiazArrastia,

Xia Xu,

Timothy D. Veenstra,

Sana M. Salih,

Shaleen K. Botting,

Rajiv Kumar

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1389

Subject(s) - pathological , estrogen , necrosis , tumor necrosis factor alpha , endometrial cancer , medicine , endocrinology , tumor necrosis factor α , cancer research , cancer

Estrogen and its metabolites play a critical role in the pathophysiology of the endometrium. The bioavailability of estrogen and estrogen metabolites in endometrial tissues depends on the expression of enzymes involved in estrogen biosynthesis and metabolism. Substantial evidence indicates that estrogen-dependent endometrial disorders are also associated with proinflammatory milieu. However, the mechanism whereby inflammation contributes to these conditions is not known.

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