Changes in Adenosine 5′-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing’s Syndrome | Zendy

Blerina Kola | Zendy; Mirjam ChristCrain | Zendy; Francesca Lolli | Zendy; Giorgio Arnaldi | Zendy; Gilberta Giacchetti | Zendy; Marco Boscaro | Zendy; Ashley Grossman | Zendy; Márta Korbonits | Zendy

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Changes in Adenosine 5′-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing’s Syndrome

Author(s) -

Blerina Kola,

Mirjam ChristCrain,

Francesca Lolli,

Giorgio Arnaldi,

Gilberta Giacchetti,

Marco Boscaro,

Ashley Grossman,

Márta Korbonits

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1297

Subject(s) - medicine , endocrinology , adipose tissue , ampk , metabolic syndrome , insulin resistance , glucocorticoid , abdominal obesity , protein kinase a , biology , insulin , kinase , obesity , microbiology and biotechnology

Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment. AMP-activated protein kinase (AMPK), a key regulatory enzyme of lipid and carbohydrate metabolism as well as appetite, is involved in the development of the deleterious metabolic effects of excess glucocorticoids, but no data are available in humans. In the current study, we demonstrate the effect of high glucocorticoid levels on AMPK activity of human adipose tissue samples from patients with Cushing's syndrome.

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