Open AccessGlucocorticoid Receptor Gene Variant in the 3′ Untranslated Region Is Associated with Multiple Measures of Blood Pressure
Author(s) -
Charles C. Chung,
Lawrence C. Shimmin,
Sivamani Natarajan,
Craig L. Hanis,
Eric Boerwinkle,
James E. Hixson
Publication year - 2009
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-1089
Subject(s) - blood pressure , single nucleotide polymorphism , biology , haplotype , endocrinology , allele , context (archaeology) , medicine , genetics , glucocorticoid receptor , pulse pressure , genotype , gene , glucocorticoid , paleontology
The glucocorticoid receptor (GR) is a key hormone in the hypothalamus-pituitary-adrenal axis that regulates many pathways including blood pressure homeostasis. Thus, GR gene variation may influence interindividual differences in blood pressure in human populations.