Reassessment of sst2Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-1 | Zendy

Thomas Fischer | Zendy; Christian Doll | Zendy; Stefan Jacobs | Zendy; Angela Kolodziej | Zendy; Ralf Stumm | Zendy; Stefan Schulz | Zendy

Open Access

Reassessment of sst₂Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-1

Author(s) -

Thomas Fischer,

Christian Doll,

Stefan Jacobs,

Angela Kolodziej,

Ralf Stumm,

Stefan Schulz

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1063

Subject(s) - monoclonal antibody , somatostatin , polyclonal antibodies , immunohistochemistry , gastrin , pathology , monoclonal , somatostatin receptor , antibody , staining , biology , antigen , antiserum , medicine , immunology , endocrinology , secretion

The overexpression of somatostatin receptor 2 (sst2) in neuroendocrine tumors is the molecular basis for diagnostic and therapeutic application of the stable somatostatin analog octreotide. Recent evidence has shown that the immunocytochemical evaluation of sst2A status is of value for predicting response to octreotide therapy and disease prognosis. However, due to the lack of monoclonal and limited availability of specific polyclonal anti-sst2A antibodies, only very few patients can currently benefit from in vitro sst2 evaluation.

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