Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells | Zendy

Tomoko Kitagawa | Zendy; Kenichi Matsuda | Zendy; Shigeki Inui | Zendy; Hideya Takenaka | Zendy; Norito Katoh | Zendy; Satoshi Itami | Zendy; Saburo Kishimoto | Zendy; Mitsuhiro Kawata | Zendy

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Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells

Author(s) -

Tomoko Kitagawa,

Kenichi Matsuda,

Shigeki Inui,

Hideya Takenaka,

Norito Katoh,

Satoshi Itami,

Saburo Kishimoto,

Mitsuhiro Kawata

Publication year - 2009

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-1053

Subject(s) - dermal papillae , wnt signaling pathway , keratinocyte , androgen , microbiology and biotechnology , cancer research , biology , medicine , endocrinology , hair follicle , signal transduction , genetics , cell culture , hormone

Androgen induces androgenetic alopecia (AGA), which has a regressive effect on hair growth from the frontal region of the scalp. Conversely, Wnt proteins are known to positively affect mammalian hair growth. We hypothesized that androgen reduces hair growth via an interaction with the Wnt signaling system. The objective of this study was to investigate the effect of androgen on Wnt signaling in dermal papilla (DP) cells.

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