Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia | Zendy

Kristel C.M.C. Koeijvoets | Zendy; Jeroen B. van der Net | Zendy; Elisabeth F. C. van Rossum | Zendy; Ewout W. Steyerberg | Zendy; Joep C. Defesche | Zendy; John J.P. Kastelein | Zendy; Steven W. J. Lamberts | Zendy; Eric J.G. Sijbrands | Zendy

Open Access

Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia

Author(s) -

Kristel C.M.C. Koeijvoets,

Jeroen B. van der Net,

Elisabeth F. C. van Rossum,

Ewout W. Steyerberg,

Joep C. Defesche,

John J.P. Kastelein,

Steven W. J. Lamberts,

Eric J.G. Sijbrands

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0813

Subject(s) - glucocorticoid receptor , glucocorticoid , haplotype , disease , context (archaeology) , medicine , familial hypercholesterolemia , gene , endocrinology , biology , genetics , cholesterol , allele , paleontology

Glucocorticoids contribute to the development of atherosclerosis. Four polymorphisms in the glucocorticoid receptor (GR) gene have been reported to alter glucocorticoid sensitivity and have been associated with cardiovascular risk factors. Studies on the relationship between these GR variants and cardiovascular disease (CVD) risk, however, have yielded conflicting results.

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