Persistence of an Intact Endometrial Matrix and Vessels Structure in Women Exposed to VA-2914, a Selective Progesterone Receptor Modulator | Zendy

Stéphanie Ravet | Zendy; Carine Munaut | Zendy; Silvia Blacher | Zendy; Géraldine Brichant | Zendy; Soraya Labied | Zendy; Aude Béliard | Zendy; Nathalie ChabbertBuffet | Zendy; Philippe Bouchard | Zendy; JeanMichel Foidart | Zendy; Axelle Pintiaux | Zendy

Open Access

Persistence of an Intact Endometrial Matrix and Vessels Structure in Women Exposed to VA-2914, a Selective Progesterone Receptor Modulator

Author(s) -

Stéphanie Ravet,

Carine Munaut,

Silvia Blacher,

Géraldine Brichant,

Soraya Labied,

Aude Béliard,

Nathalie ChabbertBuffet,

Philippe Bouchard,

JeanMichel Foidart,

Axelle Pintiaux

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0731

Subject(s) - endocrinology , immunostaining , stromal cell , medicine , vascular endothelial growth factor , endometrium , luteal phase , angiogenesis , von willebrand factor , progesterone receptor , in utero , immunohistochemistry , chemistry , andrology , biology , vegf receptors , estrogen receptor , platelet , pregnancy , fetus , cancer , breast cancer , hormone , genetics

VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal bleeding due to progestins is a consequence of focal stromal proteolysis by an increase in naked vessel size and density.

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