Control of Childhood Congenital Adrenal Hyperplasia and Sleep Activity and Quality with Morning or Evening Glucocorticoid Therapy | Zendy

Alina German | Zendy; Suheir Suraiya | Zendy; Yardena TenenbaumRakover | Zendy; Ilana Koren | Zendy; Giora Pillar | Zendy; Ze’ev Hochberg | Zendy

Open Access

Control of Childhood Congenital Adrenal Hyperplasia and Sleep Activity and Quality with Morning or Evening Glucocorticoid Therapy

Author(s) -

Alina German,

Suheir Suraiya,

Yardena TenenbaumRakover,

Ilana Koren,

Giora Pillar,

Ze’ev Hochberg

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0519

Subject(s) - morning , evening , medicine , dehydroepiandrosterone sulfate , endocrinology , testosterone (patch) , congenital adrenal hyperplasia , hydrocortisone , glucocorticoid , androstenedione , hormone , androgen , physics , astronomy

Traditionally, hydrocortisone (HC) replacement therapy in congenital adrenal hyperplasia (CAH) is given by three daily doses, albeit not necessarily of equal quantity. Although a higher dose in the morning better imitates the physiological diurnal variation, a late-night higher dose was suggested to better suppress early morning hypothalamic-pituitary-adrenal axis peak activity. Yet, increased night cortisol has been claimed to be associated with sleep disturbances and insomnia.

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