Open AccessGrowth-Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells
Author(s) -
John M. Feller,
Ann M. Simpson,
Margaret Nelson,
M. A. Swan,
Philip J. O’Connell,
Wayne J. Hawthorne,
Chang Tao,
Bronwyn A. O’Brien
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-0510
Subject(s) - islet , antibody , chemistry , endocrinology , biology , immunology , diabetes mellitus
Hyperinsulinism with islet cell hyperplasia is a frequent complication, of unknown cause, in hemolytic disease of the newborn, occurring in Rh(D)-positive infants of Rh-isoimmunized Rh(D)-negative mothers, but not in infants with other hemolytic disorders. We investigated the possibility that trans-placentally acquired anti-D Ig is the cause of both conditions.
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