A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine | Zendy

Vijay Panicker | Zendy; Christie Cluett | Zendy; Beverley M. Shields | Zendy; Anna Murray | Zendy; Kirstie Parnell | Zendy; John R. B. Perry | Zendy; Michael N. Weedon | Zendy; Andrew Singleton | Zendy; Dena Hernandez | Zendy; Jonathan Evans | Zendy; Claire Durant | Zendy; Luigi Ferrucci | Zendy; David Melzer | Zendy; Ponnusamy Saravanan | Zendy; Theo J. Visser | Zendy; Graziano Ceresini | Zendy; Andrew T. Hattersley | Zendy; Bijay Vaidya | Zendy; Colin Dayan | Zendy; Timothy M. Frayling | Zendy

Open Access

A Common Variation in Deiodinase 1 Gene DIO1 Is Associated with the Relative Levels of Free Thyroxine and Triiodothyronine

Author(s) -

Vijay Panicker,

Christie Cluett,

Beverley M. Shields,

Anna Murray,

Kirstie Parnell,

John R. B. Perry,

Michael N. Weedon,

Andrew Singleton,

Dena Hernandez,

Jonathan Evans,

Claire Durant,

Luigi Ferrucci,

David Melzer,

Ponnusamy Saravanan,

Theo J. Visser,

Graziano Ceresini,

Andrew T. Hattersley,

Bijay Vaidya,

Colin Dayan,

Timothy M. Frayling

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0397

Subject(s) - deiodinase , single nucleotide polymorphism , international hapmap project , medicine , iodothyronine deiodinase , dio2 , endocrinology , triiodothyronine , biology , snp , genetics , gene , hormone , genotype

Genetic factors influence circulating thyroid hormone levels, but the common gene variants involved have not been conclusively identified. The genes encoding the iodothyronine deiodinases are good candidates because they alter the balance of thyroid hormones. We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones.

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