Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation | Zendy

Marianne BöniSchnetzler | Zendy; Jeffrey Thorne | Zendy; Géraldine Parnaud | Zendy; Lorella Marselli | Zendy; Jan A. Ehses | Zendy; Julie KerrConte | Zendy; François Pattou | Zendy; Philippe A. Halban | Zendy; Gordon C. Weir | Zendy; Marc Y. Donath | Zendy

Open Access

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

Author(s) -

Marianne BöniSchnetzler,

Jeffrey Thorne,

Géraldine Parnaud,

Lorella Marselli,

Jan A. Ehses,

Julie KerrConte,

François Pattou,

Philippe A. Halban,

Gordon C. Weir,

Marc Y. Donath

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0396

Subject(s) - endocrinology , medicine , gene expression , biology , messenger rna , beta cell , islet , interleukin , microbiology and biotechnology , insulin , cytokine , gene , biochemistry

Elevated glucose levels impair islet function and survival, and it has been proposed that intraislet expression of IL-1beta contributes to glucotoxicity.

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