Ghrelin Receptor Gene Polymorphisms and Body Size in Children and Adults
Author(s) -
Edwin García,
Barbara Heude,
Clive J. Petry,
Maria Gueorguiev,
Zaki HassanSmith,
Antigoni Spanou,
Susan M. Ring,
David B. Dunger,
Nicholas J. Wareham,
Manjinder S. Sandhu,
Ken K. Ong,
Márta Korbonits
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2008-0366
Subject(s) - ghrelin , haplotype , single nucleotide polymorphism , growth hormone secretagogue receptor , biology , genetics , genotype , candidate gene , genetic variation , genetic association , locus (genetics) , endocrinology , body mass index , obesity , medicine , gene , receptor
The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.
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