Androstenedione Up-Regulation of Endometrial Aromatase Expression via Local Conversion to Estrogen: Potential Relevance to the Pathogenesis of Endometriosis | Zendy

Orhan Bükülmez | Zendy; Daniel B. Hardy | Zendy; Bruce R. Carr | Zendy; Richard J. Auchus | Zendy; T. Toloubeydokhti | Zendy; R. Ann Word | Zendy; Carole R. Mendelson | Zendy

Open Access

Androstenedione Up-Regulation of Endometrial Aromatase Expression via Local Conversion to Estrogen: Potential Relevance to the Pathogenesis of Endometriosis

Author(s) -

Orhan Bükülmez,

Daniel B. Hardy,

Bruce R. Carr,

Richard J. Auchus,

T. Toloubeydokhti,

R. Ann Word,

Carole R. Mendelson

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2008-0248

Subject(s) - aromatase , medicine , endocrinology , estrogen , stromal cell , androstenedione , biology , androgen , chromatin immunoprecipitation , aromatase inhibitor , testosterone (patch) , chemistry , gene expression , hormone , cancer , breast cancer , biochemistry , promoter , gene

Up-regulation of aromatase expression in endometrial cells disseminated into the peritoneal cavity may enhance their survival via local estrogen synthesis, which may lead to endometriosis. The factors that mediate induction of aromatase in the endometrium are not well defined, but increased expression of steroidogenic factor (SF)-1 may play a role.

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