Loss-of-Function Mutation of theGPR40Gene Associates with Abnormal Stimulated Insulin Secretion by Acting on Intracellular Calcium Mobilization | Zendy

Roberto Vettor | Zendy; Marnie Granzotto | Zendy; Diego De Stefani | Zendy; Elisabetta Trevellin | Zendy; Marco Rossato | Zendy; Maria Grazia Farina | Zendy; Gabriella Milan | Zendy; Catia Pilon | Zendy; A. Nigro | Zendy; Giovanni Federspil | Zendy; Riccardo Vigneri | Zendy; Libero Vitiello | Zendy; Rosario Rizzuto | Zendy; Roberto Baratta | Zendy; Lucia Frittitta | Zendy

Open Access

Loss-of-Function Mutation of theGPR40Gene Associates with Abnormal Stimulated Insulin Secretion by Acting on Intracellular Calcium Mobilization

Author(s) -

Roberto Vettor,

Marnie Granzotto,

Diego De Stefani,

Elisabetta Trevellin,

Marco Rossato,

Maria Grazia Farina,

Gabriella Milan,

Catia Pilon,

A. Nigro,

Giovanni Federspil,

Riccardo Vigneri,

Libero Vitiello,

Rosario Rizzuto,

Roberto Baratta,

Lucia Frittitta

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2680

Subject(s) - calcium in biology , intracellular , secretion , mobilization , function (biology) , insulin , mutation , endocrinology , calcium , gene , medicine , free fatty acid receptor 1 , microbiology and biotechnology , biology , receptor , genetics , agonist , history , archaeology

Free fatty acids (FFAs) acutely stimulate but chronically impair glucose-stimulated insulin secretion from beta-cells. The G protein-coupled transmembrane receptor 40 (GPR40) mediates both acute and chronic effects of FFAs on insulin secretion and plays a role in glucose homeostasis. Limited information is available on the effect of GPR40 genetic abnormalities on insulin secretion and metabolic regulation in human subjects.

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