Thirty Years of Personal Experience in Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State | Zendy

Abbas E. Kitabchi | Zendy; Guillermo E. Umpierrez | Zendy; Joseph N. Fisher | Zendy; Mary Beth Murphy | Zendy; Frankie B. Stentz | Zendy

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Thirty Years of Personal Experience in Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

Author(s) -

Abbas E. Kitabchi,

Guillermo E. Umpierrez,

Joseph N. Fisher,

Mary Beth Murphy,

Frankie B. Stentz

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2577

Subject(s) - medicine , diabetic ketoacidosis , insulin , proinflammatory cytokine , diabetes mellitus , endocrinology , prospective cohort study , ketosis , ketoacidosis , type 1 diabetes , intensive care medicine , inflammation

Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) cause major morbidity and significant mortality in patients with diabetes mellitus. For more than 30 yr, our group, in a series of prospective, randomized clinical studies, has investigated the pathogenesis and evolving strategies of the treatment of hyperglycemic crises. This paper summarizes the results of these prospective studies on the management and pathophysiology of DKA.

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