The Proinflammatory Mediator CD40 Ligand Is Increased in the Metabolic Syndrome and Modulated by Adiponectin | Zendy

Cristital | Zendy; Patricia Restituto | Zendy; C. Iñigo | Zendy; Inmaculada Colina | Zendy; Javier Dı́ez | Zendy; Nerea Varo | Zendy

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The Proinflammatory Mediator CD40 Ligand Is Increased in the Metabolic Syndrome and Modulated by Adiponectin

Author(s) -

Cristital,

Patricia Restituto,

C. Iñigo,

Inmaculada Colina,

Javier Dı́ez,

Nerea Varo

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2491

Subject(s) - adiponectin , proinflammatory cytokine , mediator , metabolic syndrome , ligand (biochemistry) , medicine , chemistry , inflammation , receptor , insulin resistance , obesity

We hypothesized that the CD40/CD40 ligand (CD40L) system is up-regulated in the metabolic syndrome (MS) and modulated by adiponectin (AN). The objectives were: 1) to compare plasma and monocyte CD40L in patients with MS and controls and its association with clinical and biochemical parameters, 2) to investigate platelets as a source of soluble CD40L (sCD40L), and 3) to analyze the effects of AN on CD40/CD40L.

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