Hyperinsulinemia Induces Insulin Resistance on Glucose and Lipid Metabolism in a Human Adipocytic Cell Line: Paracrine Interaction with Myocytes | Zendy

Sonia FernándezVeledo | Zendy; Iria Nieto-Vázquez | Zendy; Javier de Castro | Zendy; Pilar Ramos | Zendy; Silke Brüderlein | Zendy; Peter Möller | Zendy; Margarita Lorenzo | Zendy

Open Access

Hyperinsulinemia Induces Insulin Resistance on Glucose and Lipid Metabolism in a Human Adipocytic Cell Line: Paracrine Interaction with Myocytes

Author(s) -

Sonia FernándezVeledo,

Iria Nieto-Vázquez,

Javier de Castro,

Pilar Ramos,

Silke Brüderlein,

Peter Möller,

Margarita Lorenzo

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2472

Subject(s) - medicine , endocrinology , insulin resistance , hyperinsulinemia , insulin , biology , adipocyte , insulin receptor , glucose uptake , insulin receptor substrate , adipose tissue

Adipocytes release a variety of factors which deregulation could provide the basis for complications such as insulin resistance, an early defect on the onset of type 2 diabetes. Such insulin resistance can initially be overcome by compensatory hyperinsulinemia, but the prolonged presence of the hormone can be detrimental for insulin sensitivity.

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