Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine | Zendy

Audrey RobinsonWhite | Zendy; HuiPin Hsiao | Zendy; Wolfgang W. Leitner | Zendy; Elizabeth Greene | Zendy; Andrew J. Bauer | Zendy; Nancy Krett | Zendy; Maria Nesterova | Zendy; Constantine A. Stratakis | Zendy

Open Access

Protein Kinase A-Independent Inhibition of Proliferation and Induction of Apoptosis in Human Thyroid Cancer Cells by 8-Cl-Adenosine

Author(s) -

Audrey RobinsonWhite,

HuiPin Hsiao,

Wolfgang W. Leitner,

Elizabeth Greene,

Andrew J. Bauer,

Nancy Krett,

Maria Nesterova,

Constantine A. Stratakis

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2331

Subject(s) - cell growth , protein kinase a , endocrinology , medicine , apoptosis , adenosine , cancer cell , cell cycle , chemistry , biology , kinase , microbiology and biotechnology , biochemistry , cancer

Protein kinase A (PKA) affects cell proliferation in many cell types and is a potential target for cancer treatment. PKA activity is stimulated by cAMP and cAMP analogs. One such substance, 8-Cl-cAMP, and its metabolite 8-Cl-adenosine (8-Cl-ADO) are known inhibitors of cancer cell proliferation; however, their mechanism of action is controversial. We have investigated the antiproliferative effects of 8-Cl-cAMP and 8-CL-ADO on human thyroid cancer cells and determined PKA's involvement.

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