A Prospective Study of Gastric Carcinoids and Enterochromaffin-Like Cell Changes in Multiple Endocrine Neoplasia Type 1 and Zollinger-Ellison Syndrome: Identification of Risk Factors | Zendy

Marc J. Berna | Zendy; Bruno Annibale | Zendy; Massimo Marignani | Zendy; Tu Vinh Luong | Zendy; Vito D. Corleto | Zendy; Andrea Pace | Zendy; Tetsuhide Ito | Zendy; David J. Liewehr | Zendy; David Venzon | Zendy; Gianfranco Delle Fave | Zendy; Cesare Bordi | Zendy; Robert T. Jensen | Zendy

Open Access

A Prospective Study of Gastric Carcinoids and Enterochromaffin-Like Cell Changes in Multiple Endocrine Neoplasia Type 1 and Zollinger-Ellison Syndrome: Identification of Risk Factors

Author(s) -

Marc J. Berna,

Bruno Annibale,

Massimo Marignani,

Tu Vinh Luong,

Vito D. Corleto,

Andrea Pace,

Tetsuhide Ito,

David J. Liewehr,

David Venzon,

Gianfranco Delle Fave,

Cesare Bordi,

Robert T. Jensen

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2279

Subject(s) - men1 , multiple endocrine neoplasia , gastrinoma , enterochromaffin like cell , zollinger ellison syndrome , medicine , gastroenterology , biopsy , neuroendocrine tumors , pathology , gastrin , gastric mucosa , endocrine system , stomach , hormone , biology , biochemistry , secretion , gene

Multiple endocrine neoplasia type 1 (MEN1) patients frequently develop Zollinger-Ellison syndrome (ZES). These patients can develop proliferative changes of gastric enterochromaffin-like (ECL) cells and gastric carcinoids (ECL-cell tumors). ECL-cell changes have been extensively studied in sporadic ZES patients and can be precursor lesions of gastric carcinoids, but little is known about factors influencing their severity or development of carcinoids in MEN1/ZES patients.

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