A Functional Anti-Müllerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients | Zendy

Marlies E. Kevenaar | Zendy; Joop S.E. Laven | Zendy; Sharon Lie Fong | Zendy; André G. Uitterlinden | Zendy; Frank H. de Jong | Zendy; Axel P. N. Themmen | Zendy; Jenny A. Visser | Zendy

Open Access

A Functional Anti-Müllerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients

Author(s) -

Marlies E. Kevenaar,

Joop S.E. Laven,

Sharon Lie Fong,

André G. Uitterlinden,

Frank H. de Jong,

Axel P. N. Themmen,

Jenny A. Visser

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2205

Subject(s) - anti müllerian hormone , polycystic ovary , endocrinology , medicine , anovulation , hyperandrogenism , biology , androgen receptor , androgen , hormone , insulin resistance , obesity , prostate cancer , cancer

The common characteristic of polycystic ovary syndrome (PCOS) is a disturbance in the selection of the dominant follicle, resulting in anovulation. In PCOS women, serum anti-Müllerian hormone (AMH) levels are elevated. Because AMH decreases FSH sensitivity in mice, the elevated AMH levels may contribute to the disturbed follicle selection in PCOS women.

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