Open AccessInterleukin (IL)-23 Receptor Is a Major Susceptibility Gene for Graves’ Ophthalmopathy: The IL-23/T-helper 17 Axis Extends to Thyroid Autoimmunity
Author(s) -
Amanda K. Huber,
Eric S. Jacobson,
Krystian Jażdżewski,
Erlinda Concepcion,
Yaron Tomer
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2007-2190
Subject(s) - single nucleotide polymorphism , genotype , graves' disease , medicine , odds ratio , allele , rheumatoid arthritis , endocrinology , graves' ophthalmopathy , autoimmunity , immunology , case control study , autoimmune disease , biology , thyroid , genetics , gene , disease
IL-23 and its receptor (IL-23R) guide T cells toward the T-helper 17 phenotype. IL-23R single nucleotide polymorphisms (SNPs) have been associated with several autoimmune diseases, including Crohn's disease and rheumatoid arthritis.