Interleukin (IL)-23 Receptor Is a Major Susceptibility Gene for Graves’ Ophthalmopathy: The IL-23/T-helper 17 Axis Extends to Thyroid Autoimmunity | Zendy

Amanda K. Huber | Zendy; Eric M. Jacobson | Zendy; Krystian Jażdżewski | Zendy; Erlinda Concepcion | Zendy; Yaron Tomer | Zendy

Open Access

Interleukin (IL)-23 Receptor Is a Major Susceptibility Gene for Graves’ Ophthalmopathy: The IL-23/T-helper 17 Axis Extends to Thyroid Autoimmunity

Author(s) -

Amanda K. Huber,

Eric M. Jacobson,

Krystian Jażdżewski,

Erlinda Concepcion,

Yaron Tomer

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2190

Subject(s) - single nucleotide polymorphism , genotype , graves' disease , medicine , odds ratio , allele , rheumatoid arthritis , endocrinology , graves' ophthalmopathy , autoimmunity , immunology , case control study , autoimmune disease , biology , thyroid , genetics , gene , disease

IL-23 and its receptor (IL-23R) guide T cells toward the T-helper 17 phenotype. IL-23R single nucleotide polymorphisms (SNPs) have been associated with several autoimmune diseases, including Crohn's disease and rheumatoid arthritis.

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