Antithyroperoxidase Antibody-Dependent Cytotoxicity in Autoimmune Thyroid Disease | Zendy

Sandra A. Rebuffat | Zendy; Brigitte Nguyen | Zendy; Bruno Robert | Zendy; Françoise Castex | Zendy; Sylvie PéraldiRoux | Zendy

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Antithyroperoxidase Antibody-Dependent Cytotoxicity in Autoimmune Thyroid Disease

Author(s) -

Sandra A. Rebuffat,

Brigitte Nguyen,

Bruno Robert,

Françoise Castex,

Sylvie PéraldiRoux

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-2042

Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , thyroid peroxidase , autoantibody , effector , thyroid , antibody , immunology , cell culture , chemistry , medicine , biology , in vitro , biochemistry , monoclonal antibody , genetics

Thyroid antibody-dependent cytotoxicity has been reported in autoimmune thyroid disease (AITD). Indeed, the role of thyroperoxidase (TPO) autoantibodies (aAbs) in complement-mediated damage by binding to TPO expressed on the surface of human thyroid cells was demonstrated, whereas their activity in antibody-dependent cell cytotoxicity (ADCC) is not well established.

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