Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma | Zendy

Tobias Else | Zendy; Thomas J. Giordano | Zendy; Gary D. Hammer | Zendy

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Evaluation of Telomere Length Maintenance Mechanisms in Adrenocortical Carcinoma

Author(s) -

Tobias Else,

Thomas J. Giordano,

Gary D. Hammer

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1840

Subject(s) - telomere , adrenocortical carcinoma , telomerase , pathological , biology , pathology , cancer , medicine , endocrinology , genetics , dna , gene

Adrenocortical cancer (ACC) is a rare disease with an often fatal outcome. The clinical and pathological diagnosis of a malignant vs. benign adrenocortical tumor is sometimes challenging. Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions.

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