Prognostic Significance of SomaticRETOncogene Mutations in Sporadic Medullary Thyroid Cancer: A 10-Year Follow-Up Study | Zendy

Rossella Elisei | Zendy; Barbara Cosci | Zendy; Cristina Romei | Zendy; Valeria Bottici | Zendy; Giulia Renzini | Zendy; Eleonora Molinaro | Zendy; Laura Agate | Zendy; A Vivaldi | Zendy; Pinuccia Faviana | Zendy; Fulvio Basolo | Zendy; Paolo Miccoli | Zendy; Piero Berti | Zendy; Furio Pacini | Zendy; Aldo Pinchera | Zendy

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Prognostic Significance of SomaticRETOncogene Mutations in Sporadic Medullary Thyroid Cancer: A 10-Year Follow-Up Study

Author(s) -

Rossella Elisei,

Barbara Cosci,

Cristina Romei,

Valeria Bottici,

Giulia Renzini,

Eleonora Molinaro,

Laura Agate,

A Vivaldi,

Pinuccia Faviana,

Fulvio Basolo,

Paolo Miccoli,

Piero Berti,

Furio Pacini,

Aldo Pinchera

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1714

Subject(s) - somatic cell , thyroid carcinoma , medicine , medullary cavity , lymph node , stage (stratigraphy) , germline mutation , oncology , thyroid cancer , mutation , cancer , cancer research , thyroid , pathology , biology , genetics , gene , paleontology

Medullary thyroid carcinoma (MTC) is a well-differentiated thyroid tumor that maintains the typical features of C cells. An advanced stage and the presence of lymph node metastases at diagnosis have been demonstrated to be the most important bad prognostic factors. Somatic RET mutations have been found in 40-50% of MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial and have been performed in small series with short-term follow ups. The aim of this study was to verify the prognostic value of somatic RET mutations in a large series of MTCs with a long follow up.

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