Retinoic Acid (RA) Regulates 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometrium: Interaction of RA Receptors with Specificity Protein (SP) 1/SP3 for Estradiol Metabolism | Zendy

You-Hong Cheng | Zendy; Ping Yin | Zendy; Qing Xue | Zendy; Bertan Yılmaz | Zendy; Marcia I. Dawson | Zendy; Serdar E. Bulun | Zendy

Open Access

Retinoic Acid (RA) Regulates 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometrium: Interaction of RA Receptors with Specificity Protein (SP) 1/SP3 for Estradiol Metabolism

Author(s) -

You-Hong Cheng,

Ping Yin,

Qing Xue,

Bertan Yılmaz,

Marcia I. Dawson,

Serdar E. Bulun

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1536

Subject(s) - sp1 transcription factor , microbiology and biotechnology , biology , retinoic acid , retinoid x receptor , small interfering rna , transcription factor , chromatin immunoprecipitation , gene expression , medicine , endocrinology , promoter , nuclear receptor , rna , gene , biochemistry

The enzyme 17beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in endometrial epithelial cells. Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known.

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