The Mechanism for Protein Kinase C Inhibition of Androgen Production and 17α-Hydroxylase Expression in a Theca Cell Tumor Model | Zendy

Victor E. Beshay | Zendy; Jon Havelock | Zendy; Rosa Sirianni | Zendy; Ping Ye | Zendy; Takashi Suzuki | Zendy; William E. Rainey | Zendy; Bruce R. Carr | Zendy

Open Access

The Mechanism for Protein Kinase C Inhibition of Androgen Production and 17α-Hydroxylase Expression in a Theca Cell Tumor Model

Author(s) -

Victor E. Beshay,

Jon Havelock,

Rosa Sirianni,

Ping Ye,

Takashi Suzuki,

William E. Rainey,

Bruce R. Carr

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1394

Subject(s) - mechanism (biology) , androgen , theca , chemistry , protein expression , medicine , endocrinology , microbiology and biotechnology , biology , biochemistry , gene , ovary , physics , hormone , quantum mechanics

In polycystic ovary syndrome (PCOS), there is increased formation of androgens by thecal cells. Moreover, PCOS ovaries have been shown to have decreased levels of c-fos transcription factor. We hypothesize that c-fos expression inhibits 17alpha-hydroxylase 17,20 lyase (CYP17) activity in the human ovary, and its decreased expression seen in PCOS may lead to elevated CYP17 transcription, resulting in increased androgen production.

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