Open AccessGonadal Status and Body Mass Index Jointly Determine Growth Hormone (GH)-Releasing Hormone/GH-Releasing Peptide Synergy in Healthy Men
Author(s) -
Remberto Paulo,
Mihaela Cosma,
Cacia Soares-Welch,
James Bailey,
Kristi L. Mielke,
John M. Miles,
Cyril Y. Bowers,
Johannes D. Veldhuis
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2007-1388
Subject(s) - medicine , endocrinology , secretagogue , body mass index , testosterone (patch) , hormone , ghrelin , stimulation , growth hormone–releasing hormone , arginine , biology , growth hormone , amino acid , biochemistry
Sex steroid hormones potentiate whereas increased body mass index (BMI) represses GH secretion. Whether sex steroids modify the negative effect of BMI on secretagogue-induced GH secretion in men is not known. The issue is important in designing GH-stimulation regimens that are relatively insensitive to both gonadal status and adiposity.