Measurements of Islet Function and Glucose Metabolism with the Dipeptidyl Peptidase 4 Inhibitor Vildagliptin in Patients with Type 2 Diabetes | Zendy

Koichiro Azuma | Zendy; Žofia Rádiková | Zendy; Juliet Mancino | Zendy; Frederico G. S. Toledo | Zendy; Ernestine Thomas | Zendy; Cyrous O. Kangani | Zendy; Chiara Dalla Man | Zendy; Claudio Cobelli | Zendy; Jens J. Holst | Zendy; Carolyn F. Deacon | Zendy; Yan-Ling He | Zendy; Monica LiguerosSaylan | Zendy; Denise Serra | Zendy; James E. Foley | Zendy; David E. Kelley | Zendy

Open Access

Measurements of Islet Function and Glucose Metabolism with the Dipeptidyl Peptidase 4 Inhibitor Vildagliptin in Patients with Type 2 Diabetes

Author(s) -

Koichiro Azuma,

Žofia Rádiková,

Juliet Mancino,

Frederico G. S. Toledo,

Ernestine Thomas,

Cyrous O. Kangani,

Chiara Dalla Man,

Claudio Cobelli,

Jens J. Holst,

Carolyn F. Deacon,

Yan-Ling He,

Monica LiguerosSaylan,

Denise Serra,

James E. Foley,

David E. Kelley

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1369

Subject(s) - vildagliptin , islet , dipeptidyl peptidase 4 , type 2 diabetes , dipeptidyl peptidase , dipeptidyl peptidase 4 inhibitor , endocrinology , medicine , diabetes mellitus , function (biology) , chemistry , biochemistry , biology , enzyme , microbiology and biotechnology

Pharmacological inhibition with the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin prolongs the action of endogenously secreted incretin hormones leading to improved glycemic control in patients with type 2 diabetes mellitus (T2DM). We undertook a double-blinded, randomized-order, crossover study to examine the vildagliptin mechanisms of action on islet function and glucose utilization.

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