Common and Rare Alleles in Apolipoprotein B Contribute to Plasma Levels of Low-Density Lipoprotein Cholesterol in the General Population | Zendy

Marianne Benn | Zendy; Maria C. A. Stene | Zendy; Børge G. Nordestgaard | Zendy; Gorm Boje Jensen | Zendy; Rolf Steffensen | Zendy; Anne TybjærgHansen | Zendy

Open Access

Common and Rare Alleles in Apolipoprotein B Contribute to Plasma Levels of Low-Density Lipoprotein Cholesterol in the General Population

Author(s) -

Marianne Benn,

Maria C. A. Stene,

Børge G. Nordestgaard,

Gorm Boje Jensen,

Rolf Steffensen,

Anne TybjærgHansen

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1365

Subject(s) - apolipoprotein b , allele , cholesterol , plasma lipoprotein , lipoprotein , genetics , apolipoprotein c2 , apolipoprotein e , medicine , endocrinology , biology , very low density lipoprotein , gene , disease

We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels.

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