Correlation of in Vitro and in Vivo Somatotropic Adenoma Responsiveness to Somatostatin Analogs and Dopamine Agonists with Immunohistochemical Evaluation of Somatostatin and Dopamine Receptors and Electron Microscopy | Zendy

Diego Ferone | Zendy; Wouter W. de Herder | Zendy; Rosario Pivonello | Zendy; Johan M. Kros | Zendy; Peter M. van Koetsveld | Zendy; Ton de Jong | Zendy; Francesco Minuto | Zendy; Annamaria Colao | Zendy; Steven W. J. Lamberts | Zendy; Leo J. Hofland | Zendy

Open Access

Correlation of in Vitro and in Vivo Somatotropic Adenoma Responsiveness to Somatostatin Analogs and Dopamine Agonists with Immunohistochemical Evaluation of Somatostatin and Dopamine Receptors and Electron Microscopy

Author(s) -

Diego Ferone,

Wouter W. de Herder,

Rosario Pivonello,

Johan M. Kros,

Peter M. van Koetsveld,

Ton de Jong,

Francesco Minuto,

Annamaria Colao,

Steven W. J. Lamberts,

Leo J. Hofland

Publication year - 2008

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1358

Subject(s) - somatostatin , endocrinology , medicine , somatostatin receptor , acromegaly , immunohistochemistry , prolactin , adenoma , immunoelectron microscopy , somatostatin receptor 2 , somatotropic cell , pituitary adenoma , dopamine , biology , hormone , pituitary gland , growth hormone

Twenty-four pituitary adenomas from acromegalic patients (13 females, 11 males; age range 19-65 yr) were characterized for somatostatin receptor subtype 2A (sst(2A)), dopamine D(2) receptor (D(2)R), GH, and prolactin (PRL) expression by immunohistochemistry, and results correlated with the in vitro and in vivo hormone responses to octreotide and quinagolide. In nine cases, GH and PRL content was further studied by immunoelectron microscopy.

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