Sulfonation and Sialylation of Gonadotropins in Women during the Menstrual Cycle, after Menopause, and with Polycystic Ovarian Syndrome and in Men | Zendy

Leif Wide | Zendy; Tord Naessén | Zendy; Inger Sundström Poromaa | Zendy; Karin Eriksson | Zendy

Open Access

Sulfonation and Sialylation of Gonadotropins in Women during the Menstrual Cycle, after Menopause, and with Polycystic Ovarian Syndrome and in Men

Author(s) -

Leif Wide,

Tord Naessén,

Inger Sundström Poromaa,

Karin Eriksson

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1342

Subject(s) - sialic acid , endocrinology , medicine , menopause , menstrual cycle , luteinizing hormone , follicle stimulating hormone , chemistry , luteal phase , hormone , biochemistry

More basic isoforms of LH and FSH appear in blood at midcycle and more acidic after menopause. The LH isoforms are more basic in women with polycystic ovarian syndrome (PCOS). These charge alterations may reflect differences in the number of two negatively charged residues on the gonadotropins: sialic acid and sulfonated N-acetylgalactosamine, residues that modulate the half-life of the gonadotropins in blood.

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