Open AccessType 2 Deiodinase Polymorphism (Threonine 92 Alanine) Predicts l-Thyroxine Dose to Achieve Target Thyrotropin Levels in Thyroidectomized Patients
Author(s) -
Massimo Torlontano,
Cosimo Durante,
Isabella Torrente,
Umberto Crocetti,
Giovanni Augello,
Giuseppe Ronga,
Teresa Montesano,
Laura Travascio,
Antonella Verrienti,
Rocco Bruno,
Stefano Angelo Santini,
P D'Arcangelo,
Bruno Dallapiccola,
Sébastiano Filetti,
Vincenzo Trischitta
Publication year - 2008
Publication title -
the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2007-1067
Subject(s) - deiodinase , medicine , threonine , endocrinology , alanine , chemistry , thyroid , biochemistry , enzyme , thyroid hormones , amino acid , serine
Type 2 deiodinase (D2) converts T4 in T3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of TSH secretion. A common variant of the gene, threonine (Thr) 92 alanine (Ala), has been identified and associated with decreased D2 enzymatic activity.