Type 2 Deiodinase Polymorphism (Threonine 92 Alanine) Predicts l-Thyroxine Dose to Achieve Target Thyrotropin Levels in Thyroidectomized Patients | Zendy

Massimo Torlontano | Zendy; Cosimo Durante | Zendy; Isabella Torrente | Zendy; Umberto Crocetti | Zendy; Giovanni Augello | Zendy; Giuseppe Ronga | Zendy; Teresa Montesano | Zendy; Laura Travascio | Zendy; Antonella Verrienti | Zendy; Rocco Bruno | Zendy; Stefano Angelo Santini | Zendy; P D'Arcangelo | Zendy; Bruno Dallapiccola | Zendy; Sébastiano Filetti | Zendy; Vincenzo Trischitta | Zendy

Open Access

Type 2 Deiodinase Polymorphism (Threonine 92 Alanine) Predicts l-Thyroxine Dose to Achieve Target Thyrotropin Levels in Thyroidectomized Patients

Author(s) -

Massimo Torlontano,

Cosimo Durante,

Isabella Torrente,

Umberto Crocetti,

Giovanni Augello,

Giuseppe Ronga,

Teresa Montesano,

Laura Travascio,

Antonella Verrienti,

Rocco Bruno,

Stefano Angelo Santini,

P D'Arcangelo,

Bruno Dallapiccola,

Sébastiano Filetti,

Vincenzo Trischitta

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-1067

Subject(s) - deiodinase , medicine , threonine , endocrinology , alanine , chemistry , thyroid , biochemistry , enzyme , thyroid hormones , amino acid , serine

Type 2 deiodinase (D2) converts T4 in T3 in several human tissues, including hypothalamus and pituitary, and, therefore, plays a pivotal role in the negative feedback regulation of TSH secretion. A common variant of the gene, threonine (Thr) 92 alanine (Ala), has been identified and associated with decreased D2 enzymatic activity.

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