Adenovirus-Mediated Delivery of a Dominant-Negative Estrogen Receptor Gene in Uterine Leiomyoma Cells Abrogates Estrogen- and Progesterone-Regulated Gene Expression | Zendy

Memy H. Hassan | Zendy; Salama A. Salama | Zendy; Hossam M.M. Arafa | Zendy; Farid M.A. Hamada | Zendy; Ayman AlHendy | Zendy

Open Access

Adenovirus-Mediated Delivery of a Dominant-Negative Estrogen Receptor Gene in Uterine Leiomyoma Cells Abrogates Estrogen- and Progesterone-Regulated Gene Expression

Author(s) -

Memy H. Hassan,

Salama A. Salama,

Hossam M.M. Arafa,

Farid M.A. Hamada,

Ayman AlHendy

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0823

Subject(s) - estrogen , uterine leiomyoma , leiomyoma , uterine fibroids , estrogen receptor , context (archaeology) , smooth muscle , progesterone receptor , uterus , mechanism (biology) , estrogen receptor alpha , receptor , cancer research , medicine , endocrinology , biology , gynecology , pathology , cancer , paleontology , breast cancer , philosophy , epistemology

Human uterine leiomyomas are very common smooth muscle cell tumors that occur in reproductive-age women and are the leading reason for performing hysterectomies. The present study was conducted to explore the potential mechanism behind the effects exerted by dominant-negative estrogen receptors (DNERs) delivered by adenovirus to leiomyoma cells to ascertain the utility of DNERs as a novel strategy for treatment of uterine fibroids.

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