Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically Ill | Zendy

Lies Langouche | Zendy; Sarah Vander Perre | Zendy; Pieter Wouters | Zendy; André D’Hoore | Zendy; Troels Krarup Hansen | Zendy; Greet Van den Berghe | Zendy

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Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically Ill

Author(s) -

Lies Langouche,

Sarah Vander Perre,

Pieter Wouters,

André D’Hoore,

Troels Krarup Hansen,

Greet Van den Berghe

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0813

Subject(s) - hyperinsulinemia , insulin , medicine , context (archaeology) , critically ill , intensive care unit , endocrinology , intensive care , adverse effect , critical illness , pancreatic hormone , intensive care medicine , insulin resistance , biology , paleontology

Hyperglycemia and hyperinsulinemia are common in intensive care unit (ICU) patients and relate to illness severity. Intensive insulin therapy (IIT) to maintain normoglycemia reduces morbidity and mortality. Blood glucose control explains this benefit because a high insulin dose is associated with adverse outcome. Mitogenic insulin effects could theoretically explain this link.

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