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Abnormal Preantral Folliculogenesis in Polycystic Ovaries Is Associated with Increased Granulosa Cell Division
Author(s) -
S Stubbs,
Jaroslav Stark,
Stephen M. Dilworth,
Stephen Franks,
Kate Hardy
Publication year - 2007
Publication title -
the journal of clinical endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.206
H-Index - 353
eISSN - 1945-7197
pISSN - 0021-972X
DOI - 10.1210/jc.2007-0729
Subject(s) - polycystic ovary , folliculogenesis , context (archaeology) , endocrinology , medicine , ovary , granulosa cell , biology , endocrine system , abnormality , pathogenesis , insulin resistance , hormone , obesity , pregnancy , genetics , paleontology , lactation , psychiatry
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, but its etiology remains obscure. Recent data suggest that an intrinsic abnormality of early follicle development in the ovary is key to the pathogenesis of PCOS. We have recently found that in PCOS the proportion of primordial follicles is decreased with a reciprocal increase in the proportion of primary follicles.

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