Progesterone Receptor Regulates Bcl-2 Gene Expression through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells | Zendy

Ping Yin | Zendy; Zhihong Lin | Zendy; You-Hong Cheng | Zendy; Erica E. Marsh | Zendy; Hiroki Utsunomiya | Zendy; Hiroshi Ishikawa | Zendy; Qing Xue | Zendy; Scott Reierstad | Zendy; Joy Innes | Zendy; Stephen Thung | Zendy; Julie Kim | Zendy; Eugene Yujun Xu | Zendy; Serdar E. Bulun | Zendy

Open Access

Progesterone Receptor Regulates Bcl-2 Gene Expression through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells

Author(s) -

Ping Yin,

Zhihong Lin,

You-Hong Cheng,

Erica E. Marsh,

Hiroki Utsunomiya,

Hiroshi Ishikawa,

Qing Xue,

Scott Reierstad,

Joy Innes,

Stephen Thung,

Julie Kim,

Eugene Yujun Xu,

Serdar E. Bulun

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0725

Subject(s) - progesterone receptor , endocrinology , medicine , biology , chromatin immunoprecipitation , receptor , transfection , leiomyoma , apoptosis , gene expression , cell culture , promoter , gene , estrogen receptor , biochemistry , genetics , surgery , cancer , breast cancer

Uterine leiomyomas are smooth muscle cell tumors that cause irregular uterine bleeding and pregnancy loss in many reproductive-age women. Progesterone stimulates their growth, whereas treatment with progesterone receptor (PR) antagonists or selective progesterone receptor modulators shrinks these tumors. Molecular mechanisms underlying these observations are unknown.

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