Cinacalcet Hydrochloride Reduces the Serum Calcium Concentration in Inoperable Parathyroid Carcinoma | Zendy

Shonni J. Silverberg | Zendy; Mishaela R. Rubin | Zendy; Charles Faiman | Zendy; Munro Peacock | Zendy; Dolores Shoback | Zendy; Robert C. Smallridge | Zendy; L. E. Schwanauer | Zendy; Kurt Olson | Zendy; Preston Klassen | Zendy; John P. Bilezikian | Zendy

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Cinacalcet Hydrochloride Reduces the Serum Calcium Concentration in Inoperable Parathyroid Carcinoma

Author(s) -

Shonni J. Silverberg,

Mishaela R. Rubin,

Charles Faiman,

Munro Peacock,

Dolores Shoback,

Robert C. Smallridge,

L. E. Schwanauer,

Kurt Olson,

Preston Klassen,

John P. Bilezikian

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0585

Subject(s) - cinacalcet , parathyroid carcinoma , calcium , medicine , parathyroid hormone , endocrinology , nausea , gastroenterology , urology , carcinoma , secondary hyperparathyroidism

Management of inoperable parathyroid carcinoma presents a challenge because until recently, effective medical therapy was not available. Morbidity and mortality result primarily from severe hypercalcemia. We assessed the ability of the calcimimetic cinacalcet HCl to reduce serum calcium in patients with parathyroid carcinoma as well as its effect on PTH concentrations, bone turnover markers, safety, and health-related quality of life variables.

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