Putative Somatostatin Suppression Potentiates Adrenocorticotropin Secretion Driven by Ghrelin and Human Corticotropin-Releasing Hormone | Zendy

Ali Iranmanesh | Zendy; Paul C. Carpenter | Zendy; Kristi L. Mielke | Zendy; Cyril Y. Bowers | Zendy; Johannes D. Veldhuis | Zendy

Open Access

Putative Somatostatin Suppression Potentiates Adrenocorticotropin Secretion Driven by Ghrelin and Human Corticotropin-Releasing Hormone

Author(s) -

Ali Iranmanesh,

Paul C. Carpenter,

Kristi L. Mielke,

Cyril Y. Bowers,

Johannes D. Veldhuis

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0523

Subject(s) - somatostatin , endocrinology , medicine , ghrelin , peptide hormone , secretion , hormone , context (archaeology) , corticotropin releasing hormone , hypothalamus , peptide , neuropeptide , chemistry , biology , receptor , biochemistry , paleontology

Ghrelin is a 28-amino-acid Ser(3)-octanoylated peptide, and CRH is a 41-amino-acid peptide, both of which stimulate ACTH secretion. In principle, actions of these agonists could be subject to inhibitory modulation by hypothalamic somatostatin (SS).

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