Carcinogenic Hypergastrinemia: Signet-Ring Cell Carcinoma in a Patient with Multiple Endocrine Neoplasia Type 1 with Zollinger-Ellison’s Syndrome | Zendy

M. Schott | Zendy; Cornelia Sagert | Zendy; Holger S. Willenberg | Zendy; Sven Schinner | Zendy; Uwe Ramp | Zendy; Andrea Varró | Zendy; Andreas Raffel | Zendy; Claus Ferdinand Eisenberger | Zendy; Kai Zacharowski | Zendy; Aurel Perren | Zendy; Werner A. Scherbaum | Zendy

Open Access

Carcinogenic Hypergastrinemia: Signet-Ring Cell Carcinoma in a Patient with Multiple Endocrine Neoplasia Type 1 with Zollinger-Ellison’s Syndrome

Author(s) -

M. Schott,

Cornelia Sagert,

Holger S. Willenberg,

Sven Schinner,

Uwe Ramp,

Andrea Varró,

Andreas Raffel,

Claus Ferdinand Eisenberger,

Kai Zacharowski,

Aurel Perren,

Werner A. Scherbaum

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2007-0283

Subject(s) - gastrinoma , gastrin , multiple endocrine neoplasia , enterochromaffin like cell , signet ring cell carcinoma , medicine , enteroendocrine cell , cancer research , pathology , stomach , immunohistochemistry , cancer , adenocarcinoma , gastric mucosa , biology , endocrine system , hormone , gene , biochemistry , secretion

Gastric neuroendocrine tumors are rare neoplasms that originate from gastric enterochromaffin-like (ECL) cells in the oxyntic mucosa. Gastrin and its derivates have been reported to regulate epithelial cell proliferation, migration, and differentiation. Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families.

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