Lower Levels of Urinary 2-Hydroxyestrogens in Polycystic Ovary Syndrome | Zendy

Sana M. Salih | Zendy; Xia Xu | Zendy; Timothy D. Veenstra | Zendy; Antoni J. Dulęba | Zendy; Hala Fouad | Zendy; Manubai Nagamani | Zendy; Ayman AlHendy | Zendy

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Lower Levels of Urinary 2-Hydroxyestrogens in Polycystic Ovary Syndrome

Author(s) -

Sana M. Salih,

Xia Xu,

Timothy D. Veenstra,

Antoni J. Dulęba,

Hala Fouad,

Manubai Nagamani,

Ayman AlHendy

Publication year - 2007

Publication title -

the journal of clinical endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.206

H-Index - 353

eISSN - 1945-7197

pISSN - 0021-972X

DOI - 10.1210/jc.2006-2719

Subject(s) - endocrinology , polycystic ovary , medicine , catechol o methyl transferase , urinary system , follicular phase , anovulation , estrogen , biology , insulin , insulin resistance , genotype , gene , biochemistry

Women with polycystic ovary syndrome (PCOS) have anovulation due to arrested follicular maturation. The substrate (2-hydroxyestrogen) and product (2-methoxyestrogen) of catechol-O-methyl transferase (COMT) have been shown to modulate proliferation and angiogenesis of granulosa cells.

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